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. 2011 Nov 28;6(11):e27946. doi: 10.1371/journal.pone.0027946

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Xiang et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.

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(A) The rate of transition of ICAM-1-bound LFA-1 from short- to intermediate-lived states (k ₁₂) is accelerated by force. This force-accelerated transition rate is suppressed by XVA143 (red). (B) The transition rate of ICAM-1-bound LFA-1 from intermediate- to long-lived states (k ₂₃) is accelerated by force, which is nearly completely blocked by XVA143 (red). The force-dependency of transition rates is not affected by cation conditions.