Table 1. Animal and hematological measurements.
Normoxia | Chronic hypoxia | ||||
Saline | Sildenafil | IntReox | Sildenafil+IntReox | ||
Initial body weight, g | 251±2 | 248±5 | 255±9 | 250±5 | 235±6 |
Gain in body weight, g | 98±7 | −4±10* | 73±21# | 16±4$ | 25±5# |
Heart/body weight, mg·g−1 | 3.76±0.11 | 5.57±0.22* | 4.28±0.21# | 5.21±0.09$ | 3.75±0.16# |
Hematocrit | 0.51±0.02 | 0.66±0.02* | 0.65±0.01 | 0.68±0.01 | 0.62±0.01 |
Hemoglobin, g·l−1 | 158±4 | 200±7* | 202±5 | 218±3 | 205±4 |
Red blood cell count, RBC·fl−1 | 8.65±0.36 | 10.45±0.43* | 10.05±0.29 | 9.80±0.19 | 9.40±0.18 |
*, P<0.05 when comparing untreated chronic hypoxia vs. normoxia;
#, P<0.05 when comparing the various treatments vs. untreated chronic hypoxia;
$, P<0.05 when comparing the two treatments between them. All post-tests performed with the Bonferroni method.
Data are mean±SEM.
ANOVA P<0.0001 for all measurements.