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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Neurobiol Dis. 2011 Sep 10;45(1):395–408. doi: 10.1016/j.nbd.2011.08.029

Fig. 7. Increased ubiquitination observed in 24-month old Grn-/- mice.

Fig. 7

Grn-/- mice (A, D, G; n=4) have an increased number of ubiquitinated structures, largely in the neuropil, compared to age-matched Grn+/+ mice (B, E, H; n=4) in the (A-C) hippocampus, (D-F) cortex, and (G-I) thalamus. Scale bar 200 μm in (A, B), 100 μm in (D), 50 μm in (E), and 50 μm in (G, H). Percent thresholding shown in C, F, and I (Grn-/- in white, Grn+/+ in black) as mean ± SEM. Statistics denoted as p>0.05, ns; p<0.01, **; and p<0.001, ***.