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. 2011 Oct 29;12(4):1454–1464. doi: 10.1208/s12249-011-9708-9

Table III.

Summary of Results of: Model Analysis, Lack of Fit and R-square Analysis for Measured Responses

Source Y 1 Y 2 Y 3
Sum of squares P > F Sum of squares P > F Sum of squares P > F
Model analysis
Mean vs. total 953.44 25,918.13 69,559.39
Linear vs. mean 203.43 0.0115 3,817.85 0.0609 8,647.99 0.0087
2FIa vs. linear 18.75 0.7118 455.62 0.8094 1,457.86 0.3927
Quadratic vs. 2FI 81.69 0.0487 3,517.22 0.0023 3,032.47 0.0092
Cubic vs. quadratic 23.69 0.0667 238.23 0.0899 385.41 0.0628
Residual 1.12 15.44 17.04
Total 1,282.11 33,962.49 83,100.16
 
Lack of fit
Linear 124.13 0.0395 4,211.07 0.0163 4,875.74 0.0156
2FI 105.38 0.0311 3,755.45 0.0122 3,417.88 0.0148
Quadratic 23.69 0.0667 238.23 0.0899 385.41 0.0628
Cubic 0.000 0.000 0.000
Pure error 1.12 15.44 17.04
R 2 R a 2 PRESS R 2 R a 2 PRESS R 2 R a 2 PRESS
R2 analysis
Linear 0.619 0.5150 258.03 0.475 0.3313 6,764.99 0.637 0.5401 8,608.39
2FI 0.676 0.4330 524.30 0.531 0.1797 10,468.81 0.746 0.5561 10,430.84
Quadratic 0.925 0.7886 381.63 0.968 0.9117 3,846.43 0.970 0.9168 6,204.88
Cubic 0.997 0.9762 NDb 0.998 0.9866 ND 0.999 0.9912 ND

aTwo-factor interaction

bPRESS statistic not defined