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. 2011 Oct 4;12(4):1312–1323. doi: 10.1208/s12249-011-9699-6

Table V.

Fitting In Vitro Drug Release Data of the Batch V/FT6 According to Various Mathematical Models

Models Zero order First order Higuchi Korsmeyer–Peppas
Batches R 2 K o R 2 K F R 2 K H n R 2 K KP
I 0.9668 2.44 0.9274 0.0155 0.8233 0.1178 1.0194 0.9444 −1.7709
II 0.9887 3.2952 0.9884 0.0246 0.9295 0.1672 1.4547 0.9659 −1.961
III 0.91 4.4037 0.9868 0.0638 0.9655 0.2373 0.8959 0.9765 −1.1114
IV 0.9732 4.3117 0.9224 0.0616 0.9669 0.2252 0.9533 0.9922 −1.2382
V 0.9949 4.1945 0.8034 0.0631 0.9472 0.2141 0.959 0.9982 −1.2995
VI 0.972 10.233 0.9941 0.0887 0.9712 0.3055 0.7775 0.9957 −0.7675
VII 0.9351 5.761 0.9546 0.0729 0.9928 0.2421 0.3635 0.3230 −0.5058
VIII 0.9265 6.1325 0.9717 0.0762 0.9764 0.2506 0.5095 0.3681 −0.6276
IX 0.9503 5.7614 0.9879 0.0601 0.9774 0.2319 0.4763 0.3333 −0.6384
X 0.9965 4.4635 0.9888 0.0312 0.902 0.1602 0.0848 0.0066 −0.5824

n drug release exponents, K KP Korsmeyer–Peppas release constant, R 2 correlation coefficient, K 0 zero-order release rate constants, K F first-order release rate constant of different models