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Effect of Gastrodin Nasal In Situ Gels on the Writhing Response Induced by Acetic Acid in Mice (n = 10)
| Groups | Dose (mg kg−1) | Writhing times | Inhibition ratio (%) |
|---|---|---|---|
| Physiological saline | – | 8.2 ± 3.6 | – |
| I.g. gastrodin | 100 | 3.7 ± 1.2** | 54.9 |
| I.n. in situ gel | 25 | 4.7 ± 2.8* | 42.7 |
| 50 | 3.5 ± 1.4** | 57.3 | |
| 100 | 3.1 ± 1.2** | 62.2 |
*P < 0.05; **P < 0.01, compared with negative control
