Table 2.

Metabolite concentrations from five brain regions in HD

	Control			Premanifest			Manifest
	n	Mean	SD	n	Mean	SD	n	Mean	SD
Hypothalamus	11			10			9
Creatine		10.7	2.1		9.4	2.0		9.3	1.7
Choline		3.7	0.7		3.4	0.6		3.3	0.8
NAA		12.1	1.9		11.9	1.5		11.3	2.1
Glx		12.5	3.0		12.0	4.0		11.0	4.8
Myo-inositol		13.4	4.8		12.7	3.1		13.3	2.8
Lactate		1.5	1.0		1.1	1.1		1.0	1.4
Thalamus	14			13			9
Creatine		12.7	3.5		12.8	3.6		12.1	1.6
Choline		3.1	0.8		3.0	0.7		3.1	0.4
NAA		17.8	6.0		15.8	2.6		15.9	1.6
Glu/Gln		14.8	5.1		15.1	3.4		12.8	3.4
Myo-inositol		8.5	4.1		7.3	2.6		9.5	4.4
Lactate		1.1	1.0		0.5	0.7		1.8	0.9
Caudate Nucleus	12			11			5
Creatine		12.5	1.7		11.7	2.2		8.9*	1.2
Choline		3.1	0.7		2.8	0.5		2.6	0.6
NAA		12.1	2.3		10.8	2.0		9.0**	1.1
Glx		15.4	5.2		13.3	5.7		10.8	1.6
Myo-inositol		6.2	1.4		7.1	2.0		7.9	2.0
Lactate		1.2	0.9		1.5	0.9		0.5	0.8
Putamen	13			9			5
Creatine		13.6	2.3		12.1	2.2		10.9*	0.9
Choline		3.4	0.8		3.1	0.5		3.0	0.4
NAA		14.8	1.6		14.4	1.7		12.8*	0.9
Glx		16.3	3.4		14.2	3.4		11.4*	3.8
Myo-inositol		7.3	2.1		6.5	3.1		10.5	4.0
Lactate		0.8	0.6		1.0	1.3		0.3	0.4
Prefrontal	13			9			10
Creatine		9.1	2.4		9.2	1.6		9.9	2.1
Choline		2.3	0.5		2.4	0.4		2.3	0.5
NAA		11.7	2.4		11.6	1.5		11.9	3.0
Glx		11.3	2.8		9.8	2.2		13.3	4.0
Myo-inositol		9.5	2.4		8.8	1.9		11.9	4.9
Lactate		1.2	1.1		1.5	1.5		0.8	0.9

Concentrations of metabolites in the three groups. Since the water concentration and the T ₁ and T ₂ relaxation times of the individual metabolites in the specific voxels of interest are unknown at the field strength of 7 Tesla, data are expressed as relative values to the water peak in arbitrary units (AU)

NAA N-acetylaspartate, Glx glutamate + glutamine

* p < 0.05

** p < 0.005