Fig. 2.

Morphology and electrophysiology of TSC cell types revealed by biocytin labeling and electrophysiology using whole-cell patch clamp recordings in current clamp mode. Left panels are examples of biocytin-filled normal pyramidal (A), cytomegalic (B), interneuron (C), and giant (D) cells. Calibration bar in C also applies to panels A and B. Middle panels illustrate hyperpolarizing and depolarizing voltage deflections induced by negative and positive current pulses. Note the large amplitude action potential after-hyperpolarization in the interneuron (arrow), and the strong rectification in the depolarizing direction in the giant cell (arrow). No action potentials could be evoked in giant cells despite high depolarizing current intensity. Right panels show the current-voltage relationships for each cell.