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. Author manuscript; available in PMC: 2013 Jan 1.
Published in final edited form as: Neurobiol Dis. 2011 Aug 23;45(1):310–321. doi: 10.1016/j.nbd.2011.08.015

Fig. 7.

Fig. 7

A. Responses to exogenous application of GABA in dissociated normal pyramidal neurons from TSC and CDIIB samples. Top left panels are examples of pyramidal neurons from a TSC and a CDIIB case. Traces on the right are outward currents induced by increasing concentrations of GABA at a holding potential of -40 mV. At the higher concentrations, the response consisted of a fast peak followed by a rapidly desensitizing current. B. Average peak currents and current densities at increasing concentrations of GABA. At all concentrations the response was larger in cells from CDIIB compared to TSC samples. C. In addition, the EC50 was significantly reduced in cells from CDIIB samples (right bar graph), indicating higher sensitivity of GABA receptors.