Table 2.
Median (range) maximum urine concentrations (Cmax100) and times of maximum urine concentrations (tmax100) normalized to 100 mg/dL creatinine of R- and S-stereoisomers in urine after low (1.0 mg/kg) and high (1.6 mg/kg) oral MDMA administration.
| Cmax 100 (μmol/g creatinine) | t max 100 (h) | ||||
|---|---|---|---|---|---|
| R | S | R | S | ||
| MDMA | low | 49.0 (15.2-277) | 34.9 (9.5-144) | 8.4 (3.2-13.7) | 7.4 (3.2-13.4) |
| high | 140.8 (68.4-264) | 111.0 (46.6-163) | 6.5 (4.0-23.2) | 5.6 (3.1-11.3) | |
| DHMA | low | 1.1 (0.5-5.7) | 0.7 (0.2-5.3) | 13.7 (2.6-87.8) | 9.4 (2.6-87.8) |
| high | 1.8 (0.4-4.3) | 0.7 (0.3-4.4) | 8.8 (1.2-62.4) | 7.7 (0.9-23.2) | |
| DHMA sulfate | low | 57.0 (21.8-115) | 85.9 (18.7-185) | 7.9 (2.1-17.3) | 5.7 (2.1-17.3) |
| high | 81.7 (28.3-178) | 112.1 (49.3-338) | 4.5 (3.1-6.3) | 4.8 (4.0-6.3) | |
| HMMA | low | 8.5 (0.3-21.5) | 9.5 (0.4-28.0) | 3.2 (1.5-7.3) | 3.7 (1.5-8.5) |
| high | 17.6 (2.3-61.6) | 23.8 (4.2-96.6) | 4.4 (2.9-11.3) | 4.4 (2.9-11.3) | |
| HMMA sulfate | low | 49.9 (23.6-122) | 46.0 (12.8-137) | 5.7 (2.1-17.3) | 5.7 (2.1-17.3) |
| high | 63.5 (27.2-105) | 53.8 (27.4-128) | 4.40 (2.9-23.0) | 4.5 (3.1-5.3) | |
| HMMA glucuronide | low | 31.2 (10.7-151) | 51.3 (24.6-240) | 4.7 (3.2-10.0) | 4.7 (3.2-10.0) |
| high | 39.5 (9.7-107) | 84.3 (19.3-189) | 5.2 (4.3-7.3) | 5.1 (3.1-7.3) | |
| MDA | low | 2.5 (1.0-13.1) | 3.0 (1.1-17.5) | 13.5 (6.0-34.3) | 12.9 (6.0-56.4) |
| high | 3.8 (2.1-10.1) | 6.3 (3.8-12.0) | 10.3 (5.0-35.2) | 7.8 (5.0-35.2) | |