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. Author manuscript; available in PMC: 2012 Nov 23.
Published in final edited form as: Chem Biol. 2011 Nov 23;18(11):1442–1452. doi: 10.1016/j.chembiol.2011.08.011

Figure 2. Bioactivity guided de-replication of NPE 05545.

Figure 2

a. Thin layer chromatography analysis of flash column fractions from an acetone extract of XAD-16-bound culture extract from strain 05545. b. Activity of flash column fractions shown in a in FLuc enzyme assay (open square, X+A; solid triangle, 7a; open triangle, 7b, closed square, 7c; solid circle, 7d; open circle, 7e). c. Thin layer chromatography analysis of flash column fractions from an independent culture of 05545. d. Reverse HPLC of the components of flash column fraction 6c in panel C. e. Activity from the HPLC separation shown in panel C.