Figure 2.

CDX2 immunohistochemical expression. (A) Cdx2 aberrant nuclear expression in the basal layer of the squamous native esophageal epithelium close to mucosal erosion. (B-C) Strong Cdx2 nuclear immunostain in multilayered epithelium and intestinalized columnar epithelium. (D) Strong Cdx2 expression in intestinal metaplasia and aberrant Cdx2 expression in basal squamous cells of native esophageal epithelium. (E-F) Strong Cdx2 positivity in two cases of esophageal adenocarcinoma. Note in E, the contrast with the Cdx2 negative native esophageal epithelium. (Original magnifications, 40×, 20× and 10×)