Liposomes |
Amphiphilic, generally biocompatible, protect drugs from degradation |
Large size, limited stability |
Phosphatidylethanolamine, phosphatidylcholine, dioleoylphosphatidylethanolamine |
Polymeric |
Easily modified, some are biodegradable |
Large scale uniform production is difficult, some exhibit cytotoxicity |
PEG, PMLA, PGA, PLGA, block copolymers |
Micelles |
Easily modified, generally small size, biocompatible |
Limited stability |
Polyoxyethylene, polyoxypropylene, phosphatidylethanolamine |
Metals |
Unique optical properties, easily functionalized |
Not biodegradable, tend to agglomerate when exposed to physiological environment |
Gold, silver, platinum, copper |
Non-metals |
Stable and resistant to environmental changes, some possess unique physical properties |
Generally not biodegradable, some have exhibited cytotoxic effects |
Silica, carbon |