Table 3.
30-day mortality and mortality rate ratios (MRR) for patients with perforated and bleeding peptic ulcer stratified by level of comorbidity.
| Comorbidity score Ω | Age (years) | Number of patients | 30-day mortality | Crude 30-day MRR (95% CI) | Adjusted 30-day MRR* (95% CI) |
|---|---|---|---|---|---|
| Perforated Peptic ulcer | |||||
| Low | 15–64 | 616 | 6.0% | 1 (ref) | 1 (ref) |
| 65–79 | 378 | 20.9% | 3.8 (2.5–5.6) | 3.5 (2.3–5.1) | |
| 80+ | 273 | 41.0% | 8.6 (5.9–12.4) | 8.1 (5.5–11.9) | |
| Moderate | 15–64 | 161 | 16.8% | 1 (ref) | 1 (ref) |
| 65–79 | 290 | 34.8% | 2.3 (1.5–3.4) | 2.1 (1.4–3.2) | |
| 80+ | 208 | 50.0% | 3.8 (2.5–5.7) | 3.4 (2.3–5.3) | |
| High | 15–64 | 28 | 28.6% | 1 (ref) | 1 (ref) |
| 65–79 | 75 | 42.7% | 1.6 (0.8–3.6) | 1.6 (0.7–3.6) | |
| 80+ | 32 | 62.5% | 3.0 (1.3–6.7) | 2.9 (1.2–6.8) | |
| Bleeding Peptic ulcer | |||||
| Low | 15–64 | 1422 | 3.4% | 1 (ref) | 1 (ref) |
| 65–79 | 1322 | 6.7% | 2.0 (1.4–2.9) | 1.9 (1.3–2.7) | |
| 80+ | 1148 | 16.0% | 4.9 (3.6–6.8) | 4.5 (3.3–6.2) | |
| Moderate | 15–64 | 523 | 5.5% | 1 (ref) | 1 (ref) |
| 65–79 | 1139 | 13.4% | 2.5 (1.7–3.7) | 2.5 (1.7–3.7) | |
| 80+ | 1012 | 16.9% | 3.2 (2.2–4.8) | 3.2 (2.2–4.8) | |
| High | 15–64 | 141 | 9.2% | 1 (ref) | 1 (ref) |
| 65–79 | 313 | 13.7% | 1.5 (0.8–2.8) | 1.5 (0.8–2.7) | |
| 80+ | 212 | 25.0% | 2.9 (1.6–5.1) | 2.7 (1.5–4.9) | |
Ω Three levels of the index were defined: Low (no co-morbidity), medium (Charlson Index 1–2) and high (Charlson Index 3+). * Adjusted in a Cox regression model for gender, previous admissions with uncomplicated peptic ulcer and ulcer-related drug use.