Table 3.

Statistics of topology features and network motifs

	Comparative network motif		Integration motif		Maintenance motif		Cluster coefficient		Cluster coefficient > 0		Information entropy
	normal	tumor	normal	tumor	normal	tumor	normal	tumor	normal	tumor	normal	tumor
AML 1	3.94E+07	1.08E+07	541	27	6	26	0.126	0.113	1924	2344	10.94	12.35
AML 2	3.35E+07	3.35E+06	888	0	0	139	0.142	0.119	1373	1971	10.05	12.22
Breast 1	1.82E+07	1.88E+07	34	55	10	6	0.116	0.115	2234	2244	12.07	12.11
Breast 2	2.62E+07	2.39E+07	272	169	17	15	0.119	0.119	2271	2338	11.98	12.05
Cervical 1	5.04E+07	1.19E+07	614	49	4	52	0.134	0.117	1924	2538	10.89	12.12
Cervical 2	2.57E+07	1.74E+07	170	58	2	17	0.118	0.116	2081	2278	11.71	12.16
ESCC	2.52E+07	1.52E+07	70	8	0	6	0.117	0.112	2236	2435	11.99	12.55
Glioma	3.02E+07	2.28E+07	250	92	3	43	0.118	0.115	2242	2450	11.91	12.20
Head and neck	1.31E+07	1.24E+07	205	143	3	14	0.129	0.123	1712	1700	11.38	11.39
Lung 1	1.42E+07	1.40E+07	83	78	15	18	0.124	0.123	1813	1832	11.82	11.57
Lung 2	2.31E+07	1.88E+07	154	99	8	17	0.117	0.117	2137	2233	11.81	12.05
Oral tongue 1	1.84E+07	9.83E+06	231	68	1	32	0.130	0.121	1768	1912	11.42	12.04
Oral tongue 2	3.06E+07	2.15E+07	144	34	3	30	0.121	0.115	2349	2489	11.76	12.23
Pancreas 1	4.20E+07	1.37E+07	1427	115	5	79	0.123	0.114	1873	2457	11.23	12.21
Pancreas 2	4.60E+07	1.16E+07	1250	81	0	81	0.126	0.112	1866	2504	11.19	12.33
Prostate 1	1.37E+07	8.91E+06	573	398	0	3	0.130	0.126	1407	1485	11.06	11.30
Prostate 2	3.07E+07	2.29E+07	178	56	13	24	0.116	0.117	2357	2541	11.79	12.15
Renal 1	2.25E+07	2.24E+07	105	123	20	29	0.119	0.119	2181	2190	11.70	11.69
Renal 2	5.72E+07	7.05E+06	1227	116	8	116	0.138	0.118	1650	2398	10.56	12.16
Vulva	2.81E+07	2.67E+07	231	308	33	23	0.123	0.123	2299	2295	11.57	11.58
Tendency for tumor	Down		Down		Up		Down		Up		Up
Significance (P-value)	9.54E-06		5.53E-04		6.34E-04		1.05E-04		1.91E-05		8.20E-05