Figure 9.

Predicted effects of a double-reaction inhibition on the in vivo growth of Mycobacterium tuberculosis. The two inhibited reactions were isocitrate lyase (ICL) and glycerol-3-phosphate dehydrogenase (G3PD). The growth rates (in units of h^-1) were calculated based on flux balance analysis with different upper limits of the fluxes through the two reactions. The upper limits are in unit of mmol/h/gDW, i.e., mmol per hour per gram dry weight of M. tuberculosis. Panel A shows the results of the combinational inhibition using the iNJ661v network; panel B shows the in vitro iNJ661m results.