Table 3.

Role of GAP, GEF and GDI Ubiquitination

GAP/GEF/GDI	GTPase	Function	References
NF1 GAP	RAS	Neurite elongation	90
SPAR GAP	Ras	Actin polymerization, neuron growth	91, 92
NCrasGEF	Ras, Rap1	Increased cell proliferation and migration	93–97
hPEM-2	Cdc42	Actin polymerization and cell migration	63
FGD1/3	Cdc42	Cell migration and EGF signaling	98–100
RhoGDI	RhoA	Specifically inhibits RhoA activity	101, 102