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. Author manuscript; available in PMC: 2011 Nov 29.
Published in final edited form as: Dev Biol. 2011 Apr 3;354(2):208–220. doi: 10.1016/j.ydbio.2011.03.026

Figure 6. FN is required for the expression of activated forms of SMADs 2/3 at the midline.

Figure 6

A. Control and FN-null embryos (B, C) stained to detect activated forms of SMADs 2 and 3. Black arrows point at the nodes and white arrows point at the midline and indicate the approximate levels of transverse sections in A1-C1. The presence of activated pSMADs 2 and 3 is enriched in the floor plate (white-filled arrows) of control embryo (dark brown nuclei). Notice decreased levels of activated pSMADs 2/3 at the midline and the floor plate of FN-null embryos (B-C1). Dotted brackets in B1 mark neural ectoderm. Magnification is the same in panels A-C and A1-C1. All scale bars are 100 μm.