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(A) Tumor load in whole animals (13 weeks). (B) Average weight of tumor load per mouse, average weight of primary tumors, and average number of tumors per mouse at sacrifice for the same genotypes. Values shown represent mean ± SD; n = 20 for Pthrpflox/flox;Cre–, n = 18 for Pthrpflox/+;Cre–, n = 22 for PthrpWT/WT;Cre+ (controls), n = 12 for Pthrpflox/+;Cre+ (heterozygous), and n = 30 for Pthrpflox/flox;Cre+ (homozygous), **P < 0.01.
