Abstract
Intravenous injections of complete Freund's adjuvant, used by others to stimulate the reticuloendothelial system of small laboratory animals, produced granulomas resembling sarcoid in the lung of the dog. At the height of the disease, when granulomas occupied more than half of the alveolar tissues, transpulmonary arteriovenous (A-[unk]V) differences of lactate, pyruvate, and glucose were measured. When the diseased dogs breathed room air, the A-[unk]V differences of lactate and pyruvate were greater than normal; and when the dogs breathed an hypoxic mixture, the differences increased further. Hence the model affords the opportunity for studying the in vivo metabolism of diseased lungs. It may also prove useful for studying other aspects of granulomatous disease which cannot be easily approached in man.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BLOT W., SCHILD K. T., VALENTIN H., VENRATH H. Zur Frage der intrapulmonalen Oxydation und der Gültigkeit des Fickschen Prinzips. Z Kreislaufforsch. 1954 Dec;43(23-24):840–846. [PubMed] [Google Scholar]
- BUCHERL E., SCHWAB M. Zur Frage der intrapulmonalen Oxydationen. Klin Wochenschr. 1950 May 15;28(19-20):321–326. doi: 10.1007/BF01485949. [DOI] [PubMed] [Google Scholar]
- Caldwell P. R., Echeverri U., Kilcoyne M. M., Fritts H. W., Jr Observations on a model of proliferative lung disease. II. Description of pulmonary gas exchange and comparison of Fick and dye cardiac outputs. J Clin Invest. 1970 Jul;49(7):1311–1315. doi: 10.1172/JCI106346. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FRITTS H. W., Jr, RICHARDS D. W., COURNAND A. Oxygen consumption of tissues in the human lung. Science. 1961 Apr 7;133(3458):1070–1072. doi: 10.1126/science.133.3458.1070. [DOI] [PubMed] [Google Scholar]
- HARRIS P., BAILEY T., BATEMAN M., FITZGERALD M. G., GLOSTER J., HARRIS E. A., DONALD K. W. LACTATE, PYRUVATE, GLUCOSE, AND FREE FATTY ACID IN MIXED VENOUS AND ARTERIAL BLOOD. J Appl Physiol. 1963 Sep;18:933–936. doi: 10.1152/jappl.1963.18.5.933. [DOI] [PubMed] [Google Scholar]
- HUCKABEE W. E. Relationships of pyruvate and lactate during anaerobic metabolism. I. Effects of infusion of pyruvate or glucose and of hyperventilation. J Clin Invest. 1958 Feb;37(2):244–254. doi: 10.1172/JCI103603. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LAUFER A., TAL C., BEHAR A. J. Effect of adjuvant (Freund's type) and its components on the organs of various animal species; a comparative study. Br J Exp Pathol. 1959 Feb;40(1):1–7. [PMC free article] [PubMed] [Google Scholar]
- LOCHNER W., PIIPER J., SCHURMEYER E., BOSTROEM B. Uber die Grösse eines Milchsäureschwundes in der Lunge narkotisierter Hunde. Pflugers Arch. 1957;264(6):549–560. doi: 10.1007/BF00363876. [DOI] [PubMed] [Google Scholar]
- MOORE R. D., SCHOENBERG M. D. THE RESPONSE OF THE HISTIOCYTES AND MACROPHAGES IN THE LUNGS OF RABBITS INJECTED WITH FREUND'S ADJUVANT. Br J Exp Pathol. 1964 Oct;45:488–497. [PMC free article] [PubMed] [Google Scholar]
- RUPP J. C., MOORE R. D., SCHOENBERG M. D. Stimulation of the reticuloendothelial system in the rabbit by Freund's adjuvant. Arch Pathol. 1960 Jul;70:43–49. [PubMed] [Google Scholar]
- Starzecki B., Spink W. Hemodynamic effects of isoproterenol in canine endotoxin shock. J Clin Invest. 1968 Oct;47(10):2193–2205. doi: 10.1172/JCI105905. [DOI] [PMC free article] [PubMed] [Google Scholar]
- WEIBEL E. R., GOMEZ D. M. A principle for counting tissue structures on random sections. J Appl Physiol. 1962 Mar;17:343–348. doi: 10.1152/jappl.1962.17.2.343. [DOI] [PubMed] [Google Scholar]
- Zborowska-Sluis D. T., Dossetor J. B. Hyperlactatemia of hyperventilation. J Appl Physiol. 1967 Apr;22(4):746–755. doi: 10.1152/jappl.1967.22.4.746. [DOI] [PubMed] [Google Scholar]