TABLE 3.
Effect of MMN compared with placebo on HIV-related outcomes in randomized controlled trials in HIV-infected adults1
First author (reference) | Dose of micronutrients | CD4 cell count | Mortality |
Fawzi (8) | High | ↑ | ↓30% |
Jiamton (15) | High | No effect | ↓74% (in CD4 <100/μL) |
McClelland (9) | High | ↑ | Not reported |
Range (10) | High | No effect | ↓71%, MMN + Zn only |
No effect, MMN or Zn alone | |||
Semba (11) | RDA | Not reported | No effect |
Kelly (12) | RDA | No effect | ↓75% |
Kaiser (16) | High | ↑ | Not reported |
Villamor (14) | High | No effect | No effect |
MMN, multiple micronutrient supplementation; RDA, Recommended Dietary Allowance; Zn, zinc supplementation; ↑, increased; ↓, decreased.