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. 2011 Jul 1;5(3):215–227. doi: 10.4161/pri.5.3.16936

Figure 1.

Figure 1

(A) Graphic representation of the behavioral changes in C57BL6 and albino Swiss mice models of prion disease. Left, middle and right columns correspond to burrowing, open field and rod bridge performances. Top and middle rows illustrate average values to C57BL6 and albino Swiss whereas bottom row illustrate two different subgroups (ME7-E) and (ME7-L) that start to behavioral deficits early and late respectively. (B) Cluster and discriminant analysis at 18 w.p.i. to demonstrate the presence of distinct sensitivity to ME7 agent. Note that on average C57BL6 start to change burrowing at 12 w.p.i. whereas albino Swiss mice only start 4 weeks later. ME7-E start at the same time as C57BL6, whereas ME7-L 10 weeks later. Open field activity starts to increase on average at 16 w.p.i. in C57Bl6 whereas in albino Swiss mice start 6 weeks later. C57BL6 and albino Swiss mice show the onset of impairments of motor coordination at the same time (18 w.p.i.). Despite statistical significant differences between ME7-animals and NBH-animals, cluster analysis did not detect subgroups in the open field and rod bridge performances.