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Comparison of ID50 and specific infectivity in ill hamsters following intracerebral inoculation of PrPSc Brain as a 1% crude brain homogenate (25 µg), PrPSc DRM (1.35 µg) and purified PrPSc DRM-PK-PTA-G100 (0.8 µg). Isolation of PrPSc in DRMs from lipid rafts resulted in a >20-fold increase in specific infectivity relative to crude brain, but much less infectivity was found in the purified PrPSc DRM-PK-PTA-G100 fraction.
