Goal-directed resuscitation protocol for severe sepsis (employed at authors' institution). BP, blood pressure; CVP, central venous pressure; ETI, endothracheal intubation; HCT, hematocrit; MAP, mean arterial pressure; PA, pulmonary artery; SBP, systolic blood pressure; ScvO2, central venous oxygen saturation. Adapted with permission from Rivers and coworkers [7].