Table 1.

Indices of sepsis-induced tissue hypoperfusion

Measure	Details
Indices of global hypoperfusion	Hypotension
	Tachycarda
	Oliguria
	Delayed capillary refill
	Clouded sensorium
	Elevated blood lactate
	Low mixed venous O2 saturation
Indices of regional hypoperfusion	Markers of organ function
	Cardiac: myocardial ischemia
	Renal: decreased urine output, increased blood urea nitrogen and creatinine
	Hepatic: increased transaminases, increased lactate dehydrogenase, increased bilirubin
	Splanchnic: stress ulceration, ileus, malabsorbtion
	Direct assessment
	Tonometry: increased gastric mucosal CO2 tension
	Sublingual capnometry: increased sublingual CO2 tension
	Near infrared spectroscopy: decreased tissue O2 saturation
	Orthogonal polarization spectral imaging: low flow velocity score