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Cellular accumulation of [14C]ciprofloxacin (external concentration 10 μM) in HEK293 and MRP4-HEK293 cells. Uptake was measured in the presence and absence of the MRP4 inhibitor MK571 (10 μM) and the BCRP inhibitor Ko143 (1 μM). *, significant reduction in accumulation in the MRP4-HEK293 cells versus wild-type HEK293 cells, P < 0.05. n = 3 separate experiments. #, significant increases in accumulation through inhibition, P < 0.05. n = 3 separate experiments.
