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. 2011 Dec;39(12):2321–2328. doi: 10.1124/dmd.111.038323

Fig. 5.

Fig. 5.

Comparison of the dose-dependent inhibition of rodent bcrp by Ko143. A, increase in Hoechst 33342 cellular accumulation in bcrp1-MDCKII cells. B, inhibition of net ciprofloxacin flux across excised sections of rat ileum expressed as a percentage of control ciprofloxacin secretion with a donor concentration of 100 μM. Other details as in the legend to Fig. 4. Data are mean ± S.E.M. of n = 3 separate animals. Inset, ciprofloxacin permeability across excised rat ileum in the absence and presence of 100 μM verapamil.