TABLE 1.
Physiological parameters at different time points in four groups
| Baseline before CA | 1 H after Resuscitation | End of Cooling Induction, PK Baseline | 4 H after Cooling | 8 H after Cooling | |
|---|---|---|---|---|---|
| MAP | |||||
| Sham normothermia | 101.7 ± 7.5 | 92.7 ± 8.8 | 102.8 ± 13.8 | 125.8 ± 16.4 | 115 ± 15.2 |
| Sham hypothermia | 110.6 ± 29.5 | 100.3 ± 11.5 | 119.5 ± 17.4 | 131.7 ± 21.9 | 129.2 ± 14.5 |
| CA normothermia | 109 ± 27.9 | 59.3 ± 14.4† | 86.3 ± 21.3 | 110 ± 5.8 | 136.5 ± 11.9# |
| CA hypothermia | 88 ± 11.5 | 69.2 ± 16.8#,† | 138.6 ± 12.9#,† | 130.5 ± 20.5# | 126.3 ± 9.9# |
| PaCO2 | |||||
| Sham normothermia | 37.9 ± 5.9 | 36.4 ± 4.4 | 35.8 ± 4.2 | 35.2 ± 3.4 | 34.8 ± 4.4 |
| Sham hypothermia | 37.1 ± 4.5 | 37.2 ± 2.4 | 40.1 ± 5.1 | 36.8 ± 7.1 | 30.8 ± 3.7# |
| CA normothermia | 39.3 ± 3.2 | 32.4 ± 5.4# | 36.7 ± 4.1 | 39.6 ± 8.0 | 35.4 ± 5.3 |
| CA hypothermia | 36.5 ± 2.6 | 29.1 ± 2.3#,† | 49.7 ± 5.9#,† | 42.9 ± 5.5#,† | 36.9 ± 8.3 |
| Glucose | |||||
| Sham normothermia | 86.8 ± 20.2 | 65.7 ± 8.07# | 69.7 ± 10.9# | 78.2 ± 18.6 | 75.3 ± 23.5 |
| Sham hypothermia | 113.5 ± 30.7 | 76.8 ± 16.6# | 87.8 ± 19.1# | 83.8 ± 18.2# | 89.2 ± 17.4# |
| CA normothermia | 112 ± 39.9 | 63.6 ± 11.8# | 56 ± 5.5#,† | 85.2 ± 28.2# | 71 ± 30.3# |
| CA hypothermia | 92.6 ± 17.0 | 53 ± 13.4#,† | 72.8 ± 29.6# | 80.7 ± 16.7# | 73.3 ± 38.1# |
| Lactate | |||||
| Sham normothermia | 0.78 ± 0.23 | 0.78 ± 0.29 | 0.82 ± 0.36 | 0.32 ± 0.30# | 0.5 ± 0.25# |
| Sham hypothermia | 0.96 ± 0.24 | 0.9 ± 0.35 | 0.56 ± 0.23# | 0.62 ± 0.23#,† | 0.4 ± 0.34# |
| CA normothermia | 0.82 ± 0.18 | 1.40 ± 0.7† | 0.7 ± 0.4 | 0.8 ± 0.23† | 1.32 ± 1.5#,† |
| CA hypothermia | 0.96 ± 0.31 | 0.88 ± 0.48 | 0.25 ± 0.13#,† | 0.47 ± 0.25#,† | 0.38 ± 0.11#,† |
| BUN | |||||
| Sham normothermia | 24.7 ± 7.3 | 22.5 ± 4.5 | 23.5 ± 6.0 | 38 ± 12.7# | 57.8 ± 19.7# |
| Sham hypothermia | 23.2 ± 5.6 | 24 ± 3.8 | 23.2 ± 4.6 | 37.2 ± 10.3# | 49.2 ± 16.7# |
| CA normothermia | 26.5 ± 8.3 | 30.1 ± 6.2† | 32.3 ± 7.5#,† | 45 ± 9.8#,† | 66.8 ± 18.0#,† |
| CA hypothermia | 26.8 ± 7.9 | 32.2 ± 9.0#,† | 31.7 ± 5.7#,† | 46.2 ± 10.2#,† | 60.6 ± 16.8# |
| Hematocrit % | |||||
| Sham normothermia | 36.7 ± 2.9 | 35.3 ± 1.2 | 34.2 ± 1.6 | 32.3 ± 2.7# | 35 ± 1.0 |
| Sham hypothermia | 35.8 ± 1.6 | 35.4 ± 2.4 | 35 ± 1.0 | 31.6 ± 1.0# | 30.8 ± 1.7#,† |
| CA normothermia | 37 ± 2.8 | 35.5 ± 1.5 | 33.3 ± 3.2# | 30 ± 1.9# | 30.8 ± 1.6#,† |
| CA hypothermia | 37 ± 4.3 | 36.8 ± 2.1 | 37.5 ± 1.6† | 31 ± 1.3# | 32.8 ± 3.7#,† |
| pH | |||||
| Sham normothermia | 7.38 ± 0.03 | 7.38 ± 0.03 | 7.39 ± 0.03 | 7.36 ± 0.06 | 7.36 ± 0.04 |
| Sham hypothermia | 7.38 ± 0.02 | 7.45 ± 0.16 | 7.36 ± 0.01 | 7.37 ± 0.03 | 7.39 ± 0.03 |
| CA normothermia | 7.37 ± 0.03 | 7.44 ± 0.03 | 7.39 ± 0.01 | 7.38 ± 0.02 | 7.35 ± 0.06 |
| CA hypothermia | 7.39 ± 0.03 | 7.43 ± 0.03 | 7.29 ± 0.04#,† | 7.32 ± 0.05#,† | 7.33 ± 0.03# |
| Mg2+ | |||||
| Sham normothermia | 0.36 ± 0.03 | 0.37 ± 0.03 | 0.37 ± 0.04 | 0.41 ± 0.05 | 0.41 ± 0.06 |
| Sham hypothermia | 0.39 ± 0.03 | 0.39 ± 0.04 | 0.40 ± 0.03 | 0.41 ± 0.05 | 0.43 ± 0.05 |
| CA normothermia | 0.36 ± 0.04 | 0.39 ± 0.04 | 0.41 ± 0.02 | 0.43 ± 0.04# | 0.46 ± 0.06#,† |
| CA hypothermia | 0.34 ± 0.05 | 0.43 ± 0.05#,† | 0.42 ± 0.02#,† | 0.41 ± 0.05# | 0.46 ± 0.09#,† |
| K+ | |||||
| Sham normothermia | 4.75 ± 0.53 | 4.74 ± 0.40 | 4.61 ± 0.37 | 5.25 ± 0.66# | 5.62 ± 0.98# |
| Sham hypothermia | 4.91 ± 0.30 | 4.79 ± 0.24 | 4.12 ± 0.35 | 3.75 ± 0.34#,† | 4.83 ± 0.28 |
| CA normothermia | 4.78 ± 0.35 | 4.84 ± 0.31 | 4.84 ± 0.37 | 5.43 ± 0.47 | 5.97 ± 0.42# |
| CA hypothermia | 4.6 ± 0.48 | 4.73 ± 0.45 | 3.89 ± 0.36#,† | 4.83 ± 0.18 | 5.67 ± 0.9# |
#
P < 0.05 compared with the baseline time point within the same treatment group (compare within row), by one-way repeated-measures ANOVA.
†
P < 0.05 compared with the sham normothermia within the same time point (compare within column) by one-way repeated-measures ANOVA.