Fig. 2.

Acquisition of antibodies to 123 distinct PfEMP1 variants with age. Mean antibody signals (MFI) were compared among children of different age groups (<2 years, n = 11; 2–2.9 years, n = 16 or 3–4 years, n = 11) and adults (≥15 years, n = 29) and associated p values obtained as outlined in the Materials and Methods. The horizontal dashed line indicates the cutoff for significance (p ≤ 0.05). Significant (p ≤ 0.05) and insignificant (p > 0.05) VAR proteins for the children <2 years comparison to adults are indicated by the horizontal brackets. Supplemental Table S2 contains the list of the VAR proteins from left to right.