Fig. 7.

Pathways for sulfur assimilation, cysteine and methionine biosynthesis, and induction of S-box regulon genes in response to NaOCl stress. The S-box regulon gene products that are induced in the transcriptome as a result of methionine starvation provoked by the S-bacillithiolation of MetE and YxjG are bold-faced in gray. The transcriptome induction ratios are shown below the gene products. The gene products of the sulfate assimilation pathway (Sat, CysC, CysH, CysJI, CysE) are not induced upon NaOCl stress (except for CysK). The inset shows the transcriptional induction of yitJ in the wild type and ΔbshA mutant using Northern blot analysis before (co) and at different times (10, 30, 60, 90, and 120 min) after exposure to 50 μm NaOCl stress. Abbreviations: APS, adenosine-5′-phosphosulfate; PAPS, 3′-phosphoadenosine-5′-phosphosulfate; OAS, O-acetylserine; N5,N10-THF, 5,10-methylenetetrahydrofolate; N5 -THF, 5-methyltetrahydrofolate; THF, tetrahydrofolate. This figure was adapted from Tomsic et al., 2008 (52).