Fig. 4.

Fraction of physical interactions connecting (A) pathways and (B) cellular locations. Each pair of pathways or cellular locations is connected by an edge reflecting the fraction of interactions from the smaller of the two groups linking proteins in those groups (“between interactions”). The size of each node shows the number of proteins annotated for that group and the nodes' border thickness is proportional to the fraction of interactions connecting proteins inside each group (“within interactions”). Note that the two panels are at scale, i.e. pathways generally have fewer annotated proteins than cellular locations. Edges with scores below 0.14 are not shown for the sake of simplicity. The full networks have many more edges, e.g. there are physical interactions connecting the Wnt-pathway with cell adhesion.