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Neutralizing activity and affinity of anti-VLY scFvs and the respective MAbs
| Anti VLY scFv and MAb | IC50, M | Kd, M |
|---|---|---|
| scFv 9B4 (VL-VH) | 3.7 × 10-8 | 1.1 × 10-8 |
| scFv 9B4 (VH-VL) | 5.1 × 10-8 | 1.5 × 10-8 |
| scFv 23A2 (VL-VH) | 1.1 × 10-7 | 9.2 × 10-8 |
| scFv 23A2 (VH-VL) | 1.5 × 10-7 | 9.8 × 10-8 |
| MAb 9B4 | 6.7 × 10-11 | 2.9 × 10-10 |
| MAb 23A2 | 4.8 × 10-10 | 1.2 × 10-10 |
