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View full-text article in PMC

. 2011 Oct 19;10:131. doi: 10.1186/1476-4598-10-131

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Copyright ©2011 Asteriti et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Aurora-A modulates the balance of forces required for spindle pole integrity: a model. Left upper panel: in a normal mitosis balanced MT forces determine the formation of a symmetrical bipolar spindle. Arrows represent opposite-directed MT forces. Right upper panel: in Aurora-A-defective mitoses, the spindle displays fragmented poles. Lower panel: spindle pole disruption is prevented by either inactivating a MT stabiliser (ch-TOG), or weakening KT-generated (Nuf2 silencing), or inhibiting motor-associated (Eg5 inhibition) centrosome-directed MT forces in the absence of Aurora-A activity. The model suggests therefore that spindle poles fragment consequently to the imbalance in MT-generated forces in Aurora-A-defective mitoses.