Table 3.

MPPD sensitivity analysis.

MPPD input category	Altered input setting	Output alveolar mass retained (mg)	Percent change in output	Percent change in input	Sensitivity percent
Individual characteristics		Human, stochastic lung model
		1st size percentile		0.81		–34.1		—		—
		60th size percentile		1.01		–17.2		—		—
		Age-specific symmetric model:
		3-year-old child		0.16		–87.1		—		—
		Clearance rates
		0.1 × default alveolar-interstitial rate constants		1.27		3.8		–90		–4.18
		0.5 × default rate constants		1.25		2.0		–50		–4.09
		1.5 × default rate constants		1.20		–2.0		50		–3.92
		2 × default rate constants		1.18		–3.8		100		–3.76
		10 × default rate constants		0.95		–23.0		900		–2.50
Exposure scenario		Aerosol concentration
		0.01 mg/m3		0.12		–90.0		–90		100
		1 mg/m3		12.2		898		900		99.7
		10 mg/m3		122.3		9,900		9,900		100
		Breathing pattern
		Resting, 12 breaths/min; 625 mL VT		0.32		–74.1		–70		106
		Heavy exercise, 26 breaths/min; 1,923 mL VT		2.30		88.0		100		88.0
		Breathing scenario
		Nasal		1.20		–2.1		—		—
		Oral		1.25		2.0		—		—
Particle properties		Diameter
		5 nm		0.81		–33.9		–87.5		38.7
		20 nm		1.51		23.5		–50		–46.9
		50 nm		1.07		–12.7		25		–50.7
		70 nm		0.85		–30.7		75		–41.0
		100 nm		0.65		–46.6		150		–31.1
		GSD
		1		1.33		9.08		–20		–45.4
		1.6		0.90		–26.7		28.0		–95.5
		2		0.60		–51.2		60		–85.3
		2.8		0.68		–44.3		124		–35.7
		4		0.12		–90.1		220		–41.0
		Aspect ratio (length:diameter)
		1 (Baseline) (20 nm:20 nm)		1.54		0		0		—
		4 (80 nm:20 nm)		1.26		–18.3		300		–6.09
		20 (400 nm:20 nm)		1.56		1.69		1,900		0.09
		100 (2 μm:20 nm)		1.12		–27.3		9,900		–0.28
		500 (10 μm:20 nm)		0.61		–60.1		49,900		–0.12
		1,000 (20 μm:20 nm)		0.54		–65.0		99,900		–0.07
—, not applicable.