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. 2011 Nov 11;4:490. doi: 10.1186/1756-0500-4-490

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Copyright ©2011 Jensen et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Quantification of foci in DM1 patient cells and NHDF. (A and D) Fibroblasts were transduced with GFP or (B, E-F) myoD. Nuclear foci in 100 cell nuclei were counted for each sample. (A and B) NHDF cell nuclei contained no foci following tranduction with GFP or myoD. (D and E) PT cells transduced with GFP or myoD showed foci in cell nuclei. (F) Differentiated (myoD) patient fibroblasts displayed markedly changed morphology and exhibited an increase in the average as well as the maximum number of nuclear foci per cell.