Table 6.
Position weight matrix scores (PWMSs, as a proxy for splicing strength) is significantly smaller for splice sites from intron-containing genes (ICGs) whose transcripts failed to recruit U1 snRNPs (NRG for nonrecruiting group) than for those from ICGs whose transcripts bind well to U1 snRNPs (RG for recruiting group). The pattern is consistent for both 5′ ss and 3′ ss, based on two-sample t-tests assuming equal variances. Mann-Whitney tests yield the same conclusion.
| 5′ ss | 3′ ss | |||
|---|---|---|---|---|
| NRG | RG | NRG | RG | |
| PWMS mean | 8.8138 | 11.1978 | 5.3129 | 7.1762 |
| PWMS Var. | 31.5069 | 4.8646 | 13.3017 | 8.2077 |
| N | 44 | 231 | 49 | 252 |
| t | −4.6346 | −3.9257 | ||
| P | 0.0000 | 0.0001 | ||