Table 2. Cytokine gene polymorphisms in Pakistani Pulmonary Tuberculosis Patients.
| Cytokines | SNP | TBNA (166) | PTB (102) | Pmd (74) | Pad(23) | ||||
| n | % | n | % | n | % | N | % | ||
| IFN-γ GN | TT | 21 | 12.65 | 24 | 23.53 | 22 | 29.73 | 2 | 8.7 |
| (+874 T/A) | TA | 80 | 48.19 | 48 | 47.06 | 34 | 45.95 | 11 | 47.83 |
| AA | 65 | 39.16 | 30 | 29.41 | 18 | 24.32 | 10 | 43.48 | |
| χ2 | 5.49 | 10.44 | 0.31 | ||||||
| p = | 0.019 | 0.001 | 0.577 | ||||||
| IFNγ Allele | T | 122 | 36.75 | 96 | 47.06 | 78 | 52.7 | 15 | 32.61 |
| (+874 T/A) | A | 210 | 63.25 | 108 | 52.94 | 70 | 47.3 | 31 | 67.39 |
| χ2 | 5.56 | 10.7 | 0.3 | ||||||
| p = | 0.018 | 0.001 | 0.584 | ||||||
| OR | 1.53 | 1.92 | 0.83 | ||||||
| 95% CI | 1.07–2.18 | 1.30–2.84 | 0.43–1.60 | ||||||
| IL-10 GN | AA | 31 | 18.67 | 23 | 22.55 | 17 | 22.97 | 6 | 26.09 |
| (−1082 A/G) | AG | 118 | 71.08 | 64 | 62.75 | 48 | 64.86 | 11 | 47.83 |
| GG | 17 | 10.24 | 15 | 14.71 | 9 | 12.16 | 6 | 26.09 | |
| χ2 | 0.01 | 0.1 | 0.46 | ||||||
| p = | 0.933 | 0.757 | 0.498 | ||||||
| IL10 Allele | A | 152 | 45.78 | 94 | 46.08 | 66 | 44.59 | 23 | 50 |
| (−1082 A/G) | G | 180 | 54.22 | 110 | 53.92 | 82 | 55.41 | 23 | 50 |
| χ2 | 0 | 0.06 | 0.29 | ||||||
| p = | 0.947 | 0.809 | 0.591 | ||||||
| OR | 1 | 1.05 | 0.85 | ||||||
| 95% CI | 0.69–1.4 | 0.71–1.55 | 0.46–1.57 | ||||||
| TNFα GN | GG | 83 | 50 | 51 | 50 | 41 | 55.41 | 8 | 34.78 |
| (−308 G/A) | GA | 83 | 50 | 51 | 50 | 33 | 44.59 | 15 | 65.22 |
| AA | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | |
| χ2 | 0 | 0.6 | 1.86 | ||||||
| p = | 1 | 0.44 | 0.172 | ||||||
| TNFα allele | G | 249 | 75 | 153 | 75 | 115 | 77.7 | 31 | 67.39 |
| (−308 G/A) | A | 83 | 25 | 51 | 25 | 33 | 22.3 | 15 | 32.61 |
| χ2 | 0 | 0.41 | 1.22 | ||||||
| p = | 1 | 0.523 | 0.27 | ||||||
| OR | 1 | 0.86 | 1.45 | ||||||
| 95% CI | 0.70–1.50 | 0.54–1.36 | 0.75–2.82 | ||||||
| IL-6 GN | GG | 100 | 60.24 | 74 | 72.55 | 51 | 68.92 | 18 | 78.26 |
| (−174 G/C) | GC | 56 | 33.73 | 24 | 23.53 | 19 | 25.68 | 5 | 21.74 |
| CC | 10 | 6.02 | 4 | 3.92 | 4 | 5.41 | 0 | 0 | |
| χ2 | 3.79 | 1.22 | 3.31 | ||||||
| p = | (0.052) | 0.27 | 0.069 | ||||||
| IL-6 allele | G | 256 | 77.11 | 172 | 84.31 | 121 | 81.76 | 41 | 89.13 |
| C | 76 | 22.89 | 32 | 15.69 | 27 | 18.24 | 5 | 10.87 | |
| χ2 | 4.07 | 1.31 | 3.47 | ||||||
| p = | 0.044 | 0.252 | 0.063 | ||||||
| OR | 0.63 | 0.75 | 0.41 | ||||||
| 95% CI | 0.40–0.99 | 0.46–1.23 | 0.16–1.08 | ||||||
Note: Abbreviations for groups are as described in table 1. Group N is given in brackets. Groups were compared with TBNA. Pearson χ2 or Fisher exact test was performed to determine group differences. Linear by linear corrected p values are shown. Significant differences (p<0.05) are in bold. Association with protection is given in italics.