Table 4. Tables 4. IFN -γ Genotype combination: frequency and association with tuberculosis disease susceptibility and severity.
| IFNγ-IL10 | TBNA % (n = 166) | PTB% (n = 102) | p-value; χ2 | OR (95% CI) | Pmd % (n = 74 ) | P-value; χ2 | OR (95% CI) | P ad % (n = 23) | *P-value; χ2 | OR (95% CI) |
| TTHigh-AAHigh | 6.42 | 8.82 | 4.48 | 4.35 | ||||||
| TTHigh-AGInt | 8.56 | 10.78 | 5.97 | 0.00 | 0.002; 29.42 | |||||
| TTHigh-GGLow | 3.21 | 5.92 | 2.99 | 4.35 | ||||||
| TAInt-AAHigh | 5.88 | 7.84 | 2.99 | 8.7 | ||||||
| TAInt-GAInt | 38.5 | 34.31 | 43.28 | 30.43 | ||||||
| TAInt-GGLow | 3.74 | 4.9 | 2.99 | 8.7 | ||||||
| AALow-AAHigh | 5.88 | 5.88 | 5.97 | 13.04 | ||||||
| AALow-GAInt | 24.06 | 17.65 | 29.85 | 17.39 | ||||||
| AALow-GGLow | 3.74 | 5.88 | 1.49 | 13.04 | 0.0022; 5.21 | 3.59 (1.12–11.41) | ||||
| IFNγ-TNFα | ||||||||||
| TTHigh-AAHigh | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| TTHigh-GAInt | 5.42 | 12.75 | 0.048;3.92 | 2.84 (0.97–8.29) | 14.86 | 0.018; 5.56 | 3.35 (1.17–9.62) | 8.7 | ||
| TTHigh-GGLow | 7.23 | 10.78 | 14.86 | 0 | 0.01; 27.25 | |||||
| TAInt-AAHigh | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| TAInt-GAInt | 26.51 | 24.51 | 21.62 | 30.43 | ||||||
| TAInt-GGLow | 21.69 | 22.5 | 24.32 | 17.39 | ||||||
| AALow-AAHigh | 0.00 | 0.00 | 0.00 | 0.00 | ||||||
| AALow-GAInt | 18.07 | 12.75 | 8.11 | 0.036; 4.42 | 0.4 (0.16–0.96) | 26.09 | ||||
| AALow-GGLow | 21.08 | 16.67 | 16.22 | 17.39 | ||||||
| IFNγ-IL6 | ||||||||||
| TThigh-GGhigh | 4.22 | 15.69 | 0.005;8.00 | 4.57 (1.47–14.21) | 20.27 | 0.0005; 12.12 | 6.0 (1.97–18.27) | 4.35 | ||
| TThigh-GCInt | 7.83 | 6.86 | 8.11 | 4.35 | ||||||
| TThigh-CClow | 0.60 | 0.98 | 1.35 | 0.00 | ||||||
| TAInt-GGHigh | 32.53 | 30.39 | 27.03 | 34.78 | ||||||
| TAInt-GCInt | 11.45 | 14.71 | 16.22 | 13.04 | ||||||
| TAInt-CClow | 4.22 | 1.96 | 2.70 | 0.00 | ||||||
| AAlow-GGHigh | 23.49 | 26.47 | 21.62 | 39.13 | 0.014; 25.98 | 2.14 (1.16–3.96) | ||||
| AALow-GCInt | 14.46 | 1.96 | 0.002;9.78 | 0.13 (0.03–0.57) | 1.35 | 0.0005; 12.18 | 0.06 (0.01–0.48) | 4.35 | 0.013; 6.1 | 0.26 (0.08–0.81) |
| AALow-CCLow | 1.2 | 0.98 | 1.35 | 0.00 |
Note: Abbreviations same as in table 1. Number in columns indicates the frequency as percent of total in each group given in brackets.
*Uncorrected p values.
P<0.005 (underlined) was considered significant after Bonferroni correction for multiple comparisons. Values in italics indicate protection and in bold indicate susceptibility.