Figure 13.
Effects of instillation of BCG, VEGF165, and VEGF121 into the urinary bladder resulted in alterations of vascular plasticity. (A) Microvessel density (MVD) was determined by computing the area occupied by CD31+ blood vessels that was expressed as percent of the cross-sectional area. (B) Angiogenesis was defined by the proliferation of CD31+ blood vessels. For this purpose, the expression of a marker of proliferation (KI67) was calculated taking CD31+ blood vessels as region of interest (ROI).