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. 2011 Nov 7;11:16. doi: 10.1186/1472-6793-11-16

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Copyright ©2011 Saban et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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TRPV1-IR in the mouse urinary bladder. Representative photomicrograph illustrating distribution of TRPV1-IR in the urinary bladder isolated from C57BL/6 mice receiving chronic PBS instillation (A) shows TRPV1-IR extending from the base (cyan arrow) of the urothelium (white transversal bar) towards the sub-urothelium (yellow transversal bar). B) No immunostaining was observed in bladders isolated from TRPV1^-/-mice indicating that this antibody specifically identifies TRPV1-IR nerve fibers. C indicates some TRPV1-positive nerves crossing the urothelial layer (white arrows) and D illustrates TRPV1-positive nerves surrounding urothelial cells. White waved line on D highlights the bladder lumen.