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. 2011 Nov 14;3:26. doi: 10.1186/2045-824X-3-26

Figure 1.

Figure 1

A pathway regulating tumour growth i.e. cancer stem cells trigger tumour growth in response to hypoxic condition and releases the signal VEGF. The VEGF initiates the endothelial cell to proliferate and form blood vessels to vascularize the growing tumour. As soon as the tumour gets oxygenated, the tumour grows further in size.