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. 2011 Nov 29;6(11):e27860. doi: 10.1371/journal.pone.0027860

Figure 8. Effective reversal of ongoing PLP139-151-induced EAE by treatment with low doses of Y-MSPc.

Figure 8

BSF1 mice were induced to develop “classical” EAE with PLP139-151. Starting on day 21 after immunization (6–8 days after disease onset), mice with a clinical score of at least 2 were grouped into groups with equal mean clinical score (5 mice/group) and treated with indicated doses of Y-MSPc in PBS (0.5 ml) or with PBS alone on days indicated by the arrows. Results shown are the mean clinical score +/−SE of one representative experiment out of two independent experiments showing a similar pattern; *, p<0.05 compared to PBS control group; two tailed Student's t-test.