Table 3.
Logistic models for prevalence of age-related cataract *
| Factor | Gender | Group | N | Median | # Events | Main Effect p-value |
Interaction with age p-value |
Odds Ratio Age 40 |
95% Lower | 95% Upper | Odds Ratio Age 70 |
95% Lower | 95% Upper |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gender | Female | 8401 | -- | 1988 | -- | -- | -- | -- | -- | -- | -- | -- | |
| Male | 6028 | -- | 1241 | < .001 | 0.010 | 0.56 | 0.45 | 0.70 | 0.76 | 0.69 | 0.84 | ||
| Diabetes | Female | No | 7238 | -- | 1470 | -- | -- | -- | -- | -- | -- | -- | -- |
| Yes | 1163 | -- | 518 | 0.036 | 0.272 | 1.92 | 1.31 | 2.83 | 1.55 | 1.33 | 1.81 | ||
| Male | No | 4971 | -- | 804 | -- | -- | -- | -- | -- | -- | -- | -- | |
| Yes | 1057 | -- | 437 | 0.003 | 0.072 | 2.82 | 1.75 | 4.53 | 1.85 | 1.56 | 2.19 | ||
| Smoking (ever) | Female | No | 5002 | -- | 1246 | -- | -- | -- | -- | -- | -- | -- | -- |
| Yes | 1266 | -- | 157 | 0.005 | 0.006 | 0.59 | 0.39 | 0.89 | 1.31 | 0.95 | 1.81 | ||
| Male | No | 2650 | -- | 469 | -- | -- | -- | -- | -- | -- | -- | -- | |
| Yes | 1039 | -- | 91 | 0.014 | 0.032 | 0.40 | 0.20 | 0.76 | 0.95 | 0.64 | 1.40 | ||
| Steroid Use | Female | No | 7001 | -- | 1475 | -- | -- | -- | -- | -- | -- | -- | -- |
| Yes | 1400 | -- | 513 | < .001 | 0.002 | 2.44 | 1.75 | 3.42 | 1.38 | 1.15 | 1.66 | ||
| Male | No | 5109 | -- | 899 | -- | -- | -- | -- | -- | -- | -- | -- | |
| Yes | 919 | -- | 342 | 0.014 | 0.040 | 2.35 | 1.31 | 4.22 | 1.31 | 1.05 | 1.64 | ||
| Statin Use | Female | No | 5903 | -- | 995 | -- | -- | -- | -- | -- | -- | -- | -- |
| Yes | 2498 | -- | 993 | 0.261 | 0.494 | 1.39 | 0.94 | 2.05 | 1.21 | 1.04 | 1.41 | ||
| Male | No | 3541 | -- | 467 | -- | -- | -- | -- | -- | -- | -- | -- | |
| Yes | 2487 | -- | 774 | 0.474 | 0.573 | 1.25 | 0.77 | 2.03 | 1.09 | 0.90 | 1.31 | ||
| BMI Category | Female | Lowest | 2407 | 22.71 | 461 | -- | -- | -- | -- | -- | -- | -- | -- |
| Middle | 2418 | 27.36 | 571 | 0.670 | 0.563 | 0.92 | 0.66 | 1.27 | 0.88 | 0.73 | 1.06 | ||
| Highest | 2413 | 34.50 | 438 | 0.471 | 0.128 | 0.89 | 0.64 | 1.23 | 0.67 | 0.55 | 0.82 | ||
| Male | Lowest | 1657 | 24.81 | 286 | -- | -- | -- | -- | -- | -- | -- | -- | |
| Middle | 1657 | 28.38 | 295 | 0.336 | 0.203 | 0.74 | 0.45 | 1.22 | 1.04 | 0.83 | 1.30 | ||
| Highest | 1657 | 32.99 | 223 | 0.844 | 0.702 | 0.68 | 0.41 | 1.14 | 0.74 | 0.58 | 0.93 | ||
| Adjusted HDL | Female | Lowest | 1234 | 49.19 | 351 | -- | -- | -- | -- | -- | -- | -- | -- |
| Middle | 1235 | 59.30 | 224 | 0.593 | 0.637 | 1.14 | 0.72 | 1.81 | 0.93 | 0.72 | 1.21 | ||
| Highest | 1235 | 70.91 | 189 | 0.885 | 0.756 | 1.04 | 0.64 | 1.66 | 0.87 | 0.66 | 1.14 | ||
| Male | Lowest | 965 | 38.46 | 273 | -- | -- | -- | -- | -- | -- | -- | -- | |
| Middle | 965 | 46.88 | 136 | 0.594 | 0.754 | 0.81 | 0.42 | 1.56 | 0.77 | 0.58 | 1.03 | ||
| Highest | 965 | 56.73 | 135 | 0.449 | 0.384 | 1.04 | 0.55 | 1.97 | 0.78 | 0.58 | 1.04 | ||
| Antioxidant Category | Female | Lowest | 1602 | -0.79 | 374 | -- | -- | -- | -- | -- | -- | -- | -- |
| Middle | 1603 | -0.03 | 370 | 0.112 | 0.087 | 0.71 | 0.47 | 1.08 | 1.15 | 0.93 | 1.42 | ||
| Highest | 1603 | 0.66 | 327 | 0.936 | 0.956 | 0.82 | 0.55 | 1.23 | 1.06 | 0.85 | 1.32 | ||
| Male | Lowest | 1009 | -0.61 | 208 | -- | -- | -- | -- | -- | -- | -- | -- | |
| Middle | 1009 | 0.12 | 184 | 0.935 | 0.918 | 1.00 | 0.50 | 1.99 | 1.00 | 0.77 | 1.30 | ||
| Highest | 1009 | 0.80 | 171 | 0.857 | 0.825 | 0.96 | 0.48 | 1.92 | 1.03 | 0.79 | 1.36 |
* All models include age and interactions with age. Models for factors other than gender and diabetes were fit in subjects without diabetes.
BMI = body mass index; HDL = high density lipoprotein