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. 2011 Nov 29;6(11):e28147. doi: 10.1371/journal.pone.0028147

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This is an open-access article distributed under the terms of the Creative Commons Public Domain declaration, which stipulates that, once placed in the public domain, this work may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose.

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Immunostaining of lens capsule flat mounts shows cell membrane distribution of β-catenin proteins in both anterior epithelial cells and fiber cells of a P21 WT lens (A). Membrane association of β-catenin remains unchanged in EphA2(-/-) anterior lens epithelial cells, but β-catenin proteins form substantial small aggregates in both anterior epithelial cells and fiber cells of ephrin-A5(-/-) lenses (A). Scale bar, 20 µm. N-cadherin is localized at the cell boundaries of hexagonal shaped lens fibers in the WT lens section (B). In the ephrin-A5(-/-) lens section, the majority of fiber cells show normal localization of N-cadherin proteins except select abnormal fiber cells (B, arrowheads). In the EphA2(-/-) lens section, the distribution of N-cadherin proteins is severely altered with some areas lacking N-cadherin staining (B, asterisks). Scale bar, 20 µm.