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. 2011 Nov 14;11:485. doi: 10.1186/1471-2407-11-485

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Copyright ©2011 Zhou et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Mcl-1 siRNA-induced sensitization to MG132-mediated apoptosis. DLD1 cells were pretreated with control siRNA or Mcl-1 siRNA for 24 h and then treated with 1 μM MG132 for another 24 h. DMSO was used as the mock control. (A) The distribution of DLD1 cells in apoptosis measured by measured by annexin-V and propidium iodide staining using flow cytometry. Representative dot plots from one experiment of three independent experiments are shown. (B) Apoptosis percentage of DLD1 cells. The value represents means ± SD of a triplicate assay. * P < 0.01 compared with control siRNA+MG132. (C) Mcl-1 siRNA enhanced MG132-induced protein cleavages for caspases-9, caspase-3 and poly (ADP-ribose) polymerase (PARP). The data presented were from one of two independent experiments with similar results.