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. 2011 Mar 23;31(12):4714–4719. doi: 10.1523/JNEUROSCI.3722-10.2011

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Copyright © 2011 the authors 0270-6474/11/314714-06$15.00/0

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Figure 2. — 11-cis-Retinol is oxidized in Nrl^−/−Rpe65^−/− retinas. A, HPLC traces of retinoids extracted from six Nrl^−/−Rpe65^−/− (P17) retinas. After incubating (60 min) with IRBP (24 μm) alone, 11-cis-retinal (11-cRAL) was essentially absent. After treating with IRBP (24 μm) and 11-cis-retinol (11-cROL) (24 μm), 11-cis-retinal was generated in the retinas. B, 11-cis-Retinal production in isolated retinas from Nrl^−/−Rpe65^−/− mice of increasing age. The decline in 11-cis-retinal production corresponds to the loss of photoreceptors seen in Nrl^−/−Rpe65^−/− mice, suggesting that 11-cis-retinal production occurred in the photoreceptors. Data points represent mean values of 11-cis-retinal per retina obtained from three samples with four retinas used per sample.