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. Author manuscript; available in PMC: 2012 Oct 6.
Published in final edited form as: Neuron. 2011 Oct 6;72(1):72–85. doi: 10.1016/j.neuron.2011.08.022

Figure 3. Loss of Activity-Dependent MeCP2 S421 Phosphorylation Regulates Development of Inhibitory Synaptic Transmission in vivo.

Figure 3

(A) Representative traces of mIPSCs recorded from layer II/II V1 pyramidal neurons in acute cortical slices from P16–17 MeCP2 S421A knock-in mice or their wild-type littermates.

(B–C) Cumulative probability distribution of mIPSC interevent intervals (B) and amplitudes (C) recorded from MeCP2 S421A or wild-type littermates.

(D–E) Average interevent interval (D) and amplitude (E) of mIPSCs recorded from wild-type or MeCP2 S421A neurons. Data are mean ± SEM. The difference in amplitude is statistically significant, p < 0.05 by Student’s t-test.

Data shown represent 250 random events drawn from each of the wild-type (n=19) or MeCP2 S421A knock-in (n=21) cells analyzed, recorded from mice from 6 independent litters.