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. 2011 Sep 28;31(39):13870–13879. doi: 10.1523/JNEUROSCI.2652-11.2011

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Copyright © 2011 the authors 0270-6474/11/3113870-10$15.00/0

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Figure 4. — Combining individual mutations progressively reduces PNU potentiation. Single-channel traces and dwell time histograms from triple (SL+I281M; SL+V288F), single (I281M; V288F) and quadruple (SL+I281M+V288F) mutant α7 receptors in the absence (left) and presence (right) of 3 μm PNU in the pipette solution. All recordings were made in the cell-attached configuration at an applied voltage of −70 mV, with 100 μm ACh in the patch pipette. Single-channel openings are upward deflections, and all traces are shown at a bandwidth of 5 kHz.