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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Anticancer Res. 2011 Nov;31(11):3645–3657.

Figure 2. ROCK control of actin polymerization.

Figure 2

(A) Individual subunits of ATP-bound globular actin (G-actin) assemble into long filamentous polymers (F-actin), creating a double helix structure. Hydrolysis of the ATP destabilizes the polymer, causing dissolution of F-actin polymers into G-actin monomers. (B) ROCK stimulates stabilization of actin polymerization via an inhibitory phosphorylation of Lin11, Isl1, Mec3 (LIM) domain kinase (LIMK), which when active promotes ADP/cofilin-mediated actin severing.