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. Author manuscript; available in PMC: 2012 Nov 16.
Published in final edited form as: Bioconjug Chem. 2011 Oct 28;22(11):2345–2354. doi: 10.1021/bc200424r

Scheme 1.

Scheme 1

Synthesis of Multiple Pathway Quenchers. a) β-alanine, EtOH, (73%). b) SnCl2, MeOH, HCl, (71%). c) i) NaNO2, H2SO4 ii) aniline derivative iii) NaOAc (20-62%). d) KOTMS, THF (36-87%). e) i) NaNO2, HCl ii) 1H-perimidine, NaOAc. f) 5-hydroxy-2-pentanone, pTsOH (43%). g) Fast Corinth V, 1:1 THF:acetone, 0°C (14%). h) 2-cyanoethyl N,N-diisopropylchlorophosphoramidite, DIPEA.